Viruses and Vesicles: Core Bead Chromatography for Gentle Removal of Impurities

Advanced Therapy Medicinal Products (ATMPs) are often based on large, sensitive biological compounds such as viruses, vesicles or long RNA sequences. Downstream purification is often associated with low recovery of the functional entity resulting in high production costs. To expand patient access to ATMPs, it is important to establish optimized and robust process that achieve high recovery rates during product manufacturing.

In this Teach Me in 10, we are joined by Dr. Peter Guterstam, ATMP Product Manager at Cytiva. Peter explores how core bead technology can be used to achieve high recovery rates in your manufacturing process to optimize ATMP accessibility.

Further Resources

• Capto™ Core 700 and core bead technology: Overview - YouTube
• Purification of exosomes using core bead technology | Cytiva (cytivalifesciences.com)
• Capto™ Core 700 multimodal chromatography resin | Cytiva (cytivalifesciences.com)
• Scalable process for adenovirus production | Cytiva (cytivalifesciences.com)